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      m6A modification and implications for microRNAs.

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          Abstract

          RNA is chemically modified with over 100 distinct reactions. Among these reactions, methylation is probably the most extensively studied modification on the RNA molecule. Studies suggest methylation of Adenine residues (m6A) to be widespread in the transcriptome with potentially important roles in biological processes. Here, we review recent literature on m6A modification and potential implications for microRNA (miRNA) mediated gene expression regulation. These implications involve miRNA biogenesis, mRNA-miRNA interactions and m6A target selection. Understanding the extent and functions of m6A is likely to improve our understanding of the complexities of the transcriptome regulation in normal and in disease states.

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          Author and article information

          Journal
          Microrna
          MicroRNA (Shariqah, United Arab Emirates)
          Bentham Science Publishers Ltd.
          2211-5374
          May 10 2017
          Affiliations
          [1 ] Middle East Technical University - Biological Sciences Ankara. Turkey.
          Article
          MIRNA-EPUB-83409
          10.2174/2211536606666170511102219
          28494721
          f0f8a9d0-50a1-41ba-8458-b95d1738e423
          History

          3’UTR,RNA methylation,m6A,mRNA,microRNA
          3’UTR, RNA methylation, m6A, mRNA, microRNA

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