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      Glucose-Insulin Kinetics of a Bioartificial Pancreas Made of an AN69 Hydrogel Hollow Fiber Containing Porcine Islets and Implanted in Diabetic Mice

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      Artificial Organs

      Wiley

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          Most cited references 17

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          Microencapsulated islets as bioartificial endocrine pancreas.

          Single implantation of microencapsulated islets into rats with streptozotocin-induced diabetes corrected the diabetic state for 2 to 3 weeks. The microencapsulated islets remained morphologically and functionally intact throughout long-term culture studies lasting over 15 weeks.
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            Implantable biohybrid artificial organs

             C Colton (1995)
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              Bioengineering in development of the hybrid artificial pancreas.

              The hybrid artificial pancreas for treatment of diabetes consists of insulin-secreting pancreatic tissue which is surrounded by a membrane that protects the tissue from rejection by the immune system following implantation. In this paper, we review the alternative therapeutic approaches for diabetes under study and then discuss the technical requirements that must be met by a hybrid device useful to humans. Previous work on intravascular and extravascular immunoisolation devices is reviewed from the standpoint of these requirements, and three critical unresolved issues are discussed: biocompatibility, oxygen supply limitations, and prevention of immune rejection.
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                Author and article information

                Journal
                Artificial Organs
                Artificial Organs
                Wiley
                0160-564X
                1525-1594
                April 1998
                April 1998
                : 22
                : 4
                : 291-299
                Article
                10.1046/j.1525-1594.1998.05087.x
                © 1998

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