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      Effects of treatment with angiotensin‐converting enzyme inhibitor (ACEI) or angiotensin II receptor antagonist (AIIRA) on renal function and glomerular injury in subtotal nephrectomized rats

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          Abstract

          The aim of this study was to determine if treatment with angiotensin‐converting enzyme inhibitors (ACEI) or angiotensin II receptor antagonists (AIIRA) might decrease urinary albumin excretion and prevent glomerular enlargement and glomerulosclerosis in subtotal (5/6) nephrectomized rats. Morphometric image analysis of glomeruli was also performed in the subtotal nephrectomized rats. The nephrectomized rats were treated with ACEI (enalapril 100mg/l), AIIRA (L‐158,809 10 mg/l) or TRX (reserpine 5 mg/l, hydralazine 80 mg/l, and hydrochlorothiazide 25 mg/l) and euthanized at 16 weeks after renal ablation. Treatments were started at 2 weeks (early treatment: Group I) or 8 weeks (later treatment: Group II) after the ablation. ACEI and AIIRA treatments were equally and significantly effective in limiting albuminuria and progression of glomerular sclerosis. TRX was also as effective in decreasing urinary albumin excretion and preserving the renal function as ACEI or AIIRA in Group I. The improvement of albuminuria, glomerular enlargement and sclerosis after these treatments in Group II was significantly less than that in Group I. It appears that the early treatment with angiotensin converting enzyme inhibitor, angiotensin II receptor antagonist or reserpine, hydralazine and hydrochlorothiazide (TRX) may prevent glomerular injury in human patients with renal hypertension. J. Clin. Lab. Anal. 11:53–62. © 1997 Wiley‐Liss, Inc.

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          Author and article information

          Journal
          J Clin Lab Anal
          J. Clin. Lab. Anal
          10.1002/(ISSN)1098-2825
          JCLA
          Journal of Clinical Laboratory Analysis
          Wiley Subscription Services, Inc., A Wiley Company (New York )
          0887-8013
          1098-2825
          07 December 1998
          1997
          : 11
          : 1 ( doiID: 10.1002/(SICI)1098-2825(1997)11:1<>1.0.CO;2-I )
          : 53-62
          Affiliations
          [ 1 ]Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
          Author notes
          [* ]Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, 2‐1‐1 Hongo, Bunkyo‐Ku, Tokyo 113, Japan
          Article
          PMC6760726 PMC6760726 6760726 JCLA9
          10.1002/(SICI)1098-2825(1997)11:1<53::AID-JCLA9>3.0.CO;2-L
          6760726
          9021525
          Copyright © 1997 Wiley‐Liss, Inc.
          Page count
          Figures: 5, Tables: 1, References: 16, Pages: 10
          Categories
          Article
          Custom metadata
          2.0
          1997
          Converter:WILEY_ML3GV2_TO_NLMPMC version:5.6.9 mode:remove_FC converted:10.09.2019

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