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      Identification of a new angiotensin-converting enzyme (ACE) inhibitor from Thai edible plants

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      Journal: Food Chemistry
      Publisher: Elsevier BV

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          Angiotensin-converting enzyme inhibitory effects by plant phenolic compounds: a study of structure activity relationships.

          John Van Camp, Gerard Bryan Gonzales, Dorien Staljanssens … (2013)
          In this study, 22 phenolic compounds were investigated to inhibit the angiotensin-converting enzyme (ACE). Tannic acid showed the highest activity (IC50 = 230 μM). The IC50 values obtained for phenolic acids and flavonoids ranged between 0.41 and 9.3 mM. QSAR analysis confirmed that the numbers of hydroxyl groups on the benzene ring play an important role for activity of phenolic compounds and that substitution of hydroxyl groups by methoxy groups decreased activity. Docking studies indicated that phenolic acids and flavonoids inhibit ACE via interaction with the zinc ion and this interaction is stabilized by other interactions with amino acids in the active site. Other compounds, such as resveratrol and pyrogallol, may inhibit ACE via interactions with amino acids at the active site, thereby blocking the catalytic activity of ACE. These structure-function relationships are useful for designing new ACE inhibitors and potential blood-pressure-lowering compounds based on phenolic compounds.
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            Purification and identification of an angiotensin I-converting enzyme inhibitory peptide from fermented soybean extract

            Hyeon Gyu Lee, Shin Rho, Ji-Soo Lee … (2009)
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              Flavonoids from the buds of Rosa damascena inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme a reductase and angiotensin I-converting enzyme.

              Hae-Rim Kim, Kyung-Min Kwon, Yeong Kim … (2010)
              Rosa damascena has been manufactured as various food products, including tea, in Korea. A new flavonoid glycoside, kaempferol-3-O-beta-D-glucopyranosyl(1-->4)-beta-D-xylopyranoside, named roxyloside A was isolated from the buds of this plant, along with four known compounds, isoquercitrin, afzelin, cyanidin-3-O-beta-glucoside, and quercetin gentiobioside. The chemical structures of these compounds were determined by spectroscopic analyses, including FAB-MS, UV, IR, (1)H and (13)C NMR, DEPT, and 2D NMR (COSY, HSQC, and HMBC). All the isolated compounds except cyanidin-3-O-beta-glucoside exhibited high levels of inhibitory activity against 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase with IC(50) values ranging from 47.1 to 80.6 microM. Cyanidin-3-O-beta-glucoside significantly suppressed angiotensin I-converting enzyme (ACE) activity, with an IC(50) value of 138.8 microM, while the other four compounds were ineffective. These results indicate that R. damascena and its flavonoids may be effective to improve the cardiovascular system.
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                Author and article information

                Journal
                Title: Food Chemistry
                Abbreviated Title: Food Chemistry
                Publisher: Elsevier BV
                ISSN (Print): 03088146
                Publication date Created: December 2014
                Publication date (Print): December 2014
                Volume: 165
                Issue:
                Pages: 92-97
                Article
                DOI: 10.1016/j.foodchem.2014.05.080
                PubMed ID: 25038653
                SO-VID: f12872e1-574a-4a4c-9d89-19ea82bbcc64
                Copyright © © 2014
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