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      Mechanisms and functional implications of adult neurogenesis.

      1 , ,
      Cell
      Elsevier BV

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          Abstract

          The generation of new neurons is sustained throughout adulthood in the mammalian brain due to the proliferation and differentiation of adult neural stem cells. In this review, we discuss the factors that regulate proliferation and fate determination of adult neural stem cells and describe recent studies concerning the integration of newborn neurons into the existing neural circuitry. We further address the potential significance of adult neurogenesis in memory, depression, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          1097-4172
          0092-8674
          Feb 22 2008
          : 132
          : 4
          Affiliations
          [1 ] Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
          Article
          S0092-8674(08)00134-7
          10.1016/j.cell.2008.01.033
          18295581
          f1377f53-5dc7-472f-aabc-d3e0ffc845c3
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