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      Design of Antiandrogens and Their Mechanisms of Action: A Case Study (Anandron)

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          The design of a new drug is conditioned by knowledge of the biochemical mechanisms involved in the etiology of the disease to be treated. With regard to endocrine pathologies, such knowledge can be obtained in the clinic from systematic assays of urinary and plasma hormones, enzyme activities and target tissue receptor concentrations. The present paper describes the results of our assays of plasma 3α-androstanediol glucuronide, 5α-reductase and androgen receptor in prostate cancer patients. The activity of the nonsteroid antiandrogen anandron is discussed in relation to these parameters: anandron may inhibit slightly adrenal androgen biosynthesis but, in particular, counters the action of these adrenal androgens on the prostate. It does not inhibit rat prostate 5α-reductase activity but interacts with androgen receptor to exert an antiandrogen action.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          28 November 2008
          : 28
          : 2-4
          : 230-241
          aRoussel-Uclaf, Paris; bHôpital Saint-Louis, Paris, and cUA 1175 CNRS, Faculté de Médecine Nord, Marseille, France
          180948 Horm Res 1987;28:230–241
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 12
          Recent Advances in the Pharmacological Control of Gonadal Function


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