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      The Role of Hypoxia in Development of the Mammalian Embryo

      Developmental Cell
      Elsevier BV

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          Abstract

          Hypoxia inducible factor (HIF) is a transcription factor that acts in low-oxygen conditions. The cellular response to HIF activation is transcriptional upregulation of a large group of genes. Some target genes promote anaerobic metabolism to reduce oxygen consumption, while others "alleviate" hypoxia by acting non-cell-autonomously to extend and modify the surrounding vasculature. Although hypoxia is often thought of as being a pathological phenomenon, the mammalian embryo in fact develops in a low-oxygen environment, and in this context HIF has additional responsibilities. This review describes how low oxygen and HIF affect gene expression, cell behavior, and ultimately morphogenesis of the embryo and placenta. 2009 Elsevier Inc. All rights reserved.

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          Author and article information

          Journal
          Developmental Cell
          Developmental Cell
          Elsevier BV
          15345807
          December 2009
          December 2009
          : 17
          : 6
          : 755-773
          Article
          10.1016/j.devcel.2009.11.008
          20059947
          f1603f05-fd02-416c-9253-3128d0d88b98
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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