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Abstract
To investigate the effects of gastrectomy on the absorption of drugs, the blood concentrations
of the active moieties, cefcapene (CCAP) and ceftizoxime (CTIZ), were determined in
36 gastrectomized patients after oral administration of cefcapene pivoxil (CCAP-PI)
and AS-924, prodrug type cephem antibiotics with different solubility-profiles. In
patients with gastrectomy, the C(max) and AUC for CCAP-PI whose solubility depended
on the acidity of gastric juice, were lower than in the controls; whereas those for
AS-924 were comparable with values in the control group. The T(max) was affected by
the extent of gastrectomy; the T(max) value was the lowest in patients who had undergone
total gastrectomy Roux-Y, followed by Billroth II and Billroth I procedure of subtotal
gastrectomy. These results indicate the need to select drugs and to instruct gastrectomized
patients regarding dosage and administration, taking the pharmacokinetics of drugs
into consideration.