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      Mechanisms of asymmetric cell division: flies and worms pave the way.

      Nature reviews. Molecular cell biology
      Animals, Caenorhabditis elegans, cytology, Cell Cycle Proteins, metabolism, Cell Division, physiology, Cell Polarity, Centrosome, Drosophila Proteins, genetics, Drosophila melanogaster, Embryo, Nonmammalian, GTP-Binding Protein alpha Subunits, Helminth Proteins, Juvenile Hormones, Protein Folding, Receptors, Notch, Signal Transduction, Spindle Apparatus, ultrastructure, Ubiquitin-Protein Ligases

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          Abstract

          Asymmetric cell division is fundamental for generating diversity in multicellular organisms. The mechanisms that govern asymmetric cell division are increasingly well understood, owing notably to studies that were conducted in Drosophila melanogaster and Caenorhabditis elegans. Lessons learned from these two model organisms also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammals.

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