Plasma Corticosterone in Adult and Immature Rats without Olfactory Bulbs

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Abstract

Plasma corticosterone levels and the weight of adrenal glands were studied in rats deprived of olfactory bulbs. The bulbectomy was performed in two groups: (A) adult rats; and (B) 30-day-old immature rats. It was found that plasma corticosterone decreased significantly in adult rats, 30 and 45 days after bulbectomy: from 29.6 ± 1.77 to 22.2 ± 1.12 µg/100 ml (p < 0.01) 30 days directly following the operation, to 12.8 ± 2.03 (p < 0.001) after 45 days. The weight of the adrenal glands was also significantly lower: 30.5 ± 1.57 mg/100 g body weight in normal subjects and 25.5 ± 1.22 mg/100 g in those bulbectomized (p < 0.05). Bulbectomized immature rats showed corticosterone levels significantly lower than those of normal rats, 5 months following operation: 25.2± 5.1 in normal subjects and 10.1 ± 1.1 µg/100 ml in those bulbectomized (p < 0.05). The weight of the adrenal glands was, however, similar to that of normal subjects. It is concluded that the olfactory bulbs in the rat have a tonic stimulating effect upon the hypothalamus-hypophysis-adrenal complex.

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Author and article information

Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1973

Publication date (Print): 1973

Publication date (Electronic): 25 March 2008

Volume: 13

Issue: 1-2

Pages: 93-99

Affiliations

Instituto de Fisiologia ‘Prof. Dr. Oscar Orías’, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba

Article

Publisher ID: 122200 Other ID: Neuroendocrinology 1973;13:93–99

DOI: 10.1159/000122200

PubMed ID: 4779050

SO-VID: f18cfd01-a3b2-4017-aabc-36383646e8c3

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 13 December 1972

Date accepted : 02 April 1973

Page count

Pages: 7

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