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      Hematopoietic effects and mechanisms of Fufang e׳jiao jiang on radiotherapy and chemotherapy-induced myelosuppressed mice.

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          Abstract

          Fufang e׳jiao jiang (FEJ), which has been widely used in clinic to replenish qi (vital energy) and nourish blood, is a famous traditional Chinese medicine formula made up of Colla corii asini (donkey-hide gelatin prepared by stewing and concentrating from the hide of Equus asinus Linnaeus.), Radix codonopsis pilosulae (the root of Codonopsis pilosula (Franch.) Nannf.), Radix ginseng rubra (the steamed and dried root of Panax ginseng C.A. Mey.), Fructus crataegi (the fruit of Crataegus pinnatifida Bunge) and Radix rehmanniae preparata (the steamed and sun dried tuber of Rehmannia glutinosa (Gaertn.) Libosch. ex Fisch. & C.A. Mey.). The present study aimed to investigate the hematopoietic effects of FEJ on myelosuppressed mice induced by radiotherapy and chemotherapy systematically and to explore the underlying hematopoietic regulation mechanisms.

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          Author and article information

          Journal
          J Ethnopharmacol
          Journal of ethnopharmacology
          1872-7573
          0378-8741
          Mar 28 2014
          : 152
          : 3
          Affiliations
          [1 ] Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; National Glycoengineering Research Center, Shandong University, Jinan 250012, China.
          [2 ] Institute of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
          [3 ] Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; Shandong Dong-E-E-Jiao Co. Ltd., Dong׳e 252201, China.
          [4 ] Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; National Glycoengineering Research Center, Shandong University, Jinan 250012, China. Electronic address: fswang@sdu.edu.cn.
          Article
          S0378-8741(14)00113-5
          10.1016/j.jep.2014.02.012
          24534527
          f19ea4f4-13cb-40ec-a130-3331b3311879
          Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
          History

          Fufang E׳jiao Jiang (FEJ),Hematopoiesis,Mechanisms,Radiotherapy and chemotherapy induced myelosuppression

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