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      Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review

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          Abstract

          <p class="first" id="d5297084e221">Convalescent plasma and hyperimmune immunoglobulin may reduce mortality in patients with viral respiratory diseases, and are currently being investigated in trials as potential therapy for coronavirus disease 2019 (COVID-19). A thorough understanding of the current body of evidence regarding the benefits and risks is required.  OBJECTIVES: To continually assess, as more evidence becomes available, whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in treatment of people with COVID-19. </p>

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          Author and article information

          Journal
          146518
          Cochrane Database of Systematic Reviews
          Wiley
          14651858
          July 10 2020
          Affiliations
          [1 ]Cochrane Haematology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; Faculty of Medicine and University Hospital Cologne, University of Cologne; Cologne Germany
          [2 ]Transfusion Research Unit, School of Public Health and Preventive Medicine; Monash University; Melbourne Australia
          [3 ]Jon J van Rood Center for Clinical Transfusion Research; Sanquin/Leiden University Medical Center; Leiden Netherlands
          [4 ]Department of Clinical Epidemiology; Leiden University Medical Center; Leiden Netherlands
          [5 ]Systematic Review Initiative; NHS Blood and Transplant; Oxford UK
          [6 ]Clinical, Research and Development; NHS Blood and Transplant; Oxford UK
          [7 ]Sanquin Blood Bank; Amsterdam Netherlands
          [8 ]Erasmus Medical Centre; Rotterdam Netherlands
          [9 ]Haematology/Transfusion Medicine; NHS Blood and Transplant; Oxford UK
          [10 ]Cochrane Cancer, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; Faculty of Medicine and University Hospital Cologne, University of Cologne; Cologne Germany
          Article
          10.1002/14651858.CD013600.pub2
          7389743
          32648959
          f1b4ebb0-2a76-4ec6-97b1-650890dcb057
          © 2020
          History

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