+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Proopiomelanocortin Messenger RNA Levels Are Increased in the Anterior Pituitary of the Sheep Fetus after Adrenalectomy in Late Gestation

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          We have investigated the effect of bilateral adrenalectomy at 116–119 days’ gestation on the levels of the messenger (m) RNA for proopiomelanocortin (POMC) in the anterior pituitary of the fetal sheep and in the ovine placentome during late gestation (134–136 days’ gestation). After fetal adrenalectomy there was a significant (p < 0.001) and sustained increase in circulating ACTH concentrations in the adrenalectomised group (1,838 ± 155 ng/l at 130–136 days) when compared with the intact control group (131 ± 25 ng/l at 130–136 days). The mean levels of POMCmRNA relative to 18S RNA were also significantly higher (p < 0.001) in the adrenalectomised fetal sheep pituitaries (2.8 ± 0.12; n = 4) than in the intact/control fetal sheep pituitaries (1.31 ± 0.13; n = 4). In contrast to the findings in the anterior pituitary, POMCmRNA was not detected in RNA extracted from the placentomes of either the adrenalectomised or intact fetal sheep. There was also a significant arteriovenous difference in ACTH concentrations in the umbilical circulation in both adrenalectomised and intact fetal sheep at 134–136 days’ gestation. This study demonstrates therefore that the fetal adrenals act to suppress POMCmRNA levels in late gestation and also that the increase in circulating ACTH after adrenalectomy originates from the pituitary and not the placentome.

          Related collections

          Author and article information

          S. Karger AG
          03 April 2008
          : 52
          : 3
          : 297-302
          aDepartment of Physiology, Monash University, Clayton; bDepartment of Anatomy, University of Melbourne, Parkville; cMedical Research Centre, Prince Henry’s Hospital, Melbourne, Australia; dPhysiological Laboratory, Cambridge, UK
          125601 Neuroendocrinology 1990;52:297–302
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Original Paper


          Comment on this article