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      Hypothalamic tanycytes: potential roles in the control of feeding and energy balance

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          Abstract

          Tanycytes, glial-like cells that line the third ventricle, are emerging as components of the hypothalamic networks that control body weight and energy balance. They contact the cerebrospinal fluid (CSF) and send processes that come into close contact with neurons in the arcuate and ventromedial hypothalamic nuclei. Tanycytes are glucosensitive and are able to respond to transmitters associated with arousal and the drive to feed. At least some tanycytes are stem cells and, in the median eminence, may be stimulated by diet to generate new neurons. The quest is on to understand how tanycytes detect and respond to changes in energy balance and how they communicate with the rest of the nervous system to effect their functions.

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          Author and article information

          Contributors
          Journal
          Trends Neurosci
          Trends Neurosci
          Trends in Neurosciences
          Elsevier Applied Science Publishing
          0166-2236
          1878-108X
          1 February 2013
          February 2013
          : 36
          : 2
          : 91-100
          Affiliations
          School of Life Sciences, University of Warwick, Coventry, UK
          Article
          S0166-2236(12)00223-8
          10.1016/j.tins.2012.12.008
          3605593
          23332797
          © 2013 Elsevier Ltd.

          This document may be redistributed and reused, subject to certain conditions.

          Categories
          Review
          Special Issue: Neural Control of Appetite

          Neurosciences

          hypothalamus, tanycyte, energy balance, chemosensor, neural stem cell

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