Acupuncture for pediatric bilateral amblyopia

Abstract

Amblyopia is defined as a reduction in best-corrected visual acuity (BCVA) of one or both eyes caused by conditions that affect abnormal visual development. It can be classified as strabismus, refractive, visual deprivation, and occlusion. Refractive amblyopia can be further classified into unilateral (anisometropic) or bilateral (isoametropic) amblyopia. Bilateral amblyopia can develop in children with a large degree of refractive error and/or astigmatism in both eyes, and the severity of the refractive error is reported to be directly related to amblyopia from the effect of blurred retinal images. According to an earlier study, spectacle correction for one year improved the bilateral refractive amblyopia in 74% of children (3–10 years). 1 Patching or atropine had to be performed in the sensitive period in patients who did not respond to spectacle correction, however, there is a controversy regarding its effectiveness, especially in children aged more than 7 years. 2 Acupuncture is widely used in to treat ophthalmological diseases in Asian countries, and several studies have demonstrated its efficacy in amblyopia. 3 However, no study has reported the efficacy of acupuncture in bilateral amblyopia. Herein, we present cases with bilateral amblyopia who failed to respond spectacle correction but showed improvement after acupuncture treatment. We retrospectively reviewed the medical records of patients who visited the Kimjoongho Korean Medical Clinic for bilateral refractive amblyopia. Patients having used spectacles for more than 12 months and aged between 5–13 years at the initial visit, with binocular visual acuity below 20/30 and spherical equivalent below -6.0 D or above 4.0 D and who consented for acupuncture treatment for six consecutive months were considered.1, 4 Patients were excluded if the interval between treatments was reported to be more than four weeks, the presence of neuro-ophthalmic conditions including strabismus or other abnormalities in the ocular media and retina was detected, or if other treatments such as patching or citicoline were initiated during the treatment period. Acupuncture treatment was performed by a Korean medical physician with over 10 years of experience. Stainless steel needles (30 mm long and 0.25 mm in diameter; Dong Bang, Gyeonggi-do, Korea) were applied at 15 acupuncture points (LI4, BL1, BL2, GB14, TE23, Ex-HN5, and ST2 in bilateral, and EX-HN1 in unilateral). Needles were superficially pricked in children without Deqi. The acupuncture procedure lasted 15 min and had an infrared heat lamp over the eye to keep it warm. We recorded the patients’ BCVA at baseline and after six months using Han’s visual chart, 5 spherical equivalent and astigmatism at baseline, and the number of treatments sessions. Since Han’s visual chart was devised before the revision of the international standard in 1994, the visual acuity line interval was considered as 0.1. Selected patients included 4 boys and 3 girls with an average age of 9.26 years who underwent an average of 45.14 treatment sessions (Table 1). The binocular visual acuity improved above 20/30 after the acupuncture treatment in 4 patients (Case 2, 5, 6, and 7) that included 3 patients who had passed through the sensitive period (aged > 7). There were no adverse events reported during the treatment. Table 1 Patients’ characteristics and changes in visual acuity before and after the six-month acupuncture treatment. Table 1 Case Gender (M/F) Age (year) Treatment sessions Sphericalequivalent (OD/OS) Astigmatism (OD/OS) Visual acuity (OD/OS) Baseline After six-month treatment 1 M 5.11 46 −6.5/−6.75 −1.5/−1.75 0.2/0.2 0.4/0.3 2 F 6.4 53 6.75/4.25 −0.5/−1.5 0.4/0.4 0.7/0.7a 3 F 8.6 45 −6.25/−8.5 −1/−1.5 0.5/0.3 0.8/0.3 4 F 10.2 55 −8.75/−7.75 −/− 0.4/0.5 0.6/0.9 5 M 10.9 36 −6.75/−7.5 −3/−2.25 0.4/0.5 0.7/0.8a 6 M 11.5 44 −6.25/−6.25 −0.5/−1 0.4/0.5 0.7/0.8a 7 M 12.1 37 −6.25/−6.75 −2.25/−1.75 0.4/0.4 0.7/0.7a Total 4/3 9.26 ± 2.66 45.14 ± 7.20 0.39 ± 0.09 / 0.40 ± 0.12 0.66 ± 0.13 / 0.64 ± 0.24 a The case’s binocular visual acuity was above 20/30 after six-month of acupuncture treatment. Bilateral amblyopia is generally considered to be resulting from an insufficient stimulation to the cerebral cortex due to the input of blurred retinal images. Acupuncture increases brain-derived neurotrophic factor (BDNF) in retinal cells, are known to improve visual function by regulating the production of dopamine and thus aiding in the recovery of amblyopia.6, 7 Earlier studies have reported that the retinal blood flow in children with amblyopia was reduced, 8 but it increased when the visual acuity was restored. 9 Peripheral acupuncture stimulates provides a local stimulus to the eye and increases retinal blood flow circulation, 10 thereby improving visual acuity. A limitation of this study was that the effects of optical correction could not be excluded completely, and to overcome this limitation, the study included the patients who failed one year of spectacle correction. We could not follow up for the treatment effect. Because the patients were subsequently received acupuncture treatment after evaluation. Moreover, a generalization of study results in case studies is never advisable. In spite of these limitations, this study is meaningful as it presents the first case series of bilateral amblyopia that improved with acupuncture treatment. Further studies exploring the efficacy of acupuncture in bilateral amblyopia as an adjuvant or salvage treatment would be worthwhile and interesting to conduct. Author contribution BK: Conceptualization, Methodology, Investigation, Writing - original draft, Writing - review & editing. MHK: Conceptualization, Writing - Review & Editing. JK: Conceptualization, Resources, Writing - Review & Editing. SP: Conceptualization, Investigation, Writing - review & editing. IC: Conceptualization, Writing - Review & Editing. Conflicts of interest The authors have no conflicts of interest to declare. Funding No financial support was received during the study. Ethical statement Parents of patients agreed using medical records. The institutional review boards approved this research (KOMCIRB 2018-09-008-001). Data availability Data will be made available upon request.