Contributors
Michael G Anderson: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
8
July
2016
Publication date Collection: 2016
Volume: 11
Issue: 7
Electronic Location Identifier: e0157404
Affiliations
[1
]Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY,
10029, United States of America
[2
]Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029,
United States of America
[3
]Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount
Sinai, New York, NY, 10029, United States of America
[4
]Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New
York, NY, 10003, United States of America
University of Iowa, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: AMB JMW RR. Performed the experiments: AW
SG ZW. Analyzed the data: AMB JMW AW CI RG. Contributed reagents/materials/analysis
tools: AMB JMW CI RG. Wrote the paper: AMB JMW RR.
Article
Publisher ID:
PONE-D-15-55129
DOI: 10.1371/journal.pone.0157404
PMC ID: 4938507
PubMed ID: 27391778
SO-VID: f1d42d8e-d7f5-40c5-89e6-4acea26baeaa
Copyright © © 2016 Want et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 20
December
2015
Date
accepted
: 27
May
2016
Page count
Figures: 7,
Tables: 1,
Pages: 21
Funding
Funded by: The Research to Prevent Blindness
Award Recipient
:
Audrey M Bernstein
Funded by: The MYS Family U.S. Charitable Foundation, Inc
Award Recipient
:
Audrey M Bernstein
Funded by: The Bright Focus Foundation
Award Recipient
:
Audrey M Bernstein
Funded by: The Glaucoma Foundation
Award Recipient
:
Audrey M Bernstein
Funded by: funder-id http://dx.doi.org/10.13039/100000053, National Eye Institute;
Award ID: EY024942
Award Recipient
:
Audrey M Bernstein
Funded by: The Research to Prevent Blindness
Award Recipient
:
J Mario Wolosin
Funded by: The MYS Family U.S. Charitable Foundation, Inc.
Award Recipient
:
J Mario Wolosin
Funded by: The Bright Focus Foundation
Award Recipient
:
J Mario Wolosin
Funded by: The Glaucoma Foundation
Award Recipient
:
J Mario Wolosin
Funded by: funder-id http://dx.doi.org/10.13039/100000053, National Eye Institute;
Award ID: EY018748
Award Recipient
:
J Mario Wolosin
Funded by: funder-id http://dx.doi.org/10.13039/100000057, National Institute of General Medical Sciences;
Award ID: T32 GM062754
Award Recipient
:
Stephanie R Gillespie
This work was supported by The Research to Prevent Blindness (AMB, JMW, and CI), The
MYS Family U.S. Charitable Foundation, Inc., The Bright Focus Foundation, and The
Glaucoma Foundation (AMB and JMW), NIH-NEI R01 EY024942 (AMB), NIH-NEI R01 EY018748
(JMW), NIH training grant T32 GM062754 (SRG), NIH-NEI EY022639 (CI). Microscopy and
image analysis was performed at the Microscopy CORE. The authors would like to thank
Leica and Mount Sinai’s Microscopy CORE for providing access to the Leica TCS SP8
STED3X. The authors gratefully acknowledge the contribution of the surgeons who supplied
surgical specimens: Dr. Celso Tello, (Manhattan Eye and Ear and Throat Hospital);
Dr. Sung Chul Park (Manhattan Eye and Ear and Throat Hospital); Dr. Jeffrey Liebmann
(Columbia University Medical Center); Dr. Brian Campollataro (New York Eye and Ear
Infirmary of Mount Sinai). The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Lysosomes
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Death
Subject:
Autophagic Cell Death
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Bioenergetics
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Extracellular Matrix Proteins
Subject:
Medicine and Health Sciences
Subject:
Ophthalmology
Subject:
Eye Diseases
Subject:
Glaucoma
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Vesicles
Subject:
Endosomes
Subject:
Physical Sciences
Subject:
Physics
Subject:
Electromagnetic Radiation
Subject:
Light
Subject:
Light Scattering
Subject:
Physical Sciences
Subject:
Physics
Subject:
Scattering
Subject:
Light Scattering
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
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