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      • Record: found
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      • Article: found

      Flow Cytometric Analysis of Surface Antigens on Human Conjunctival Epithelial Cells

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          Abstract

          We analyzed the levels of expression of different surface adhesion molecules on normal human conjunctival epithelial cells with cytology and flow cytometry. The levels of β<sub>1</sub> (CD29), VLA-1 (CD49a), VLA-2 (CD49b), and VLA-3 (CD49c) integrins were high, whereas those of VLA-5 (CD49e) and VLA-6 (CD49f) were faint, and that of VLA-4 (CD49d) was undetectable. Among the β<sub>2</sub> integrins, the levels of Mac-1 (CD1 lb) and p 150.25 (CD 11 c) were positive, while LFA-1 (CD 11 a) was not detectable. HLA class I and class II were also expressed. However, CR2 (CD21), CD57, CD44 and ICAM-1 (CD54) were not detected. Our study suggests that these techniques may aid in identifying changes in the expression levels of various surface antigens on conjunctival epithelial cells that could occur in ocular surface disease.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1997
          Publication date (Print): 1997
          Publication date (Electronic): 11 December 2009
          Volume: 29
          Issue: 2
          Pages: 103-109
          Affiliations
          aDepartment of Ophthalmology, Tokyo Dental College, Chiba, bSanten Pharmaceutical Co., Ltd., Nara Research and Development Center, Nara, and cDepartment of Internal Medicine, Saitama Medical Center, Saitama Medical School, Saitama, Japan
          Article
          Publisher ID: 268003 Other ID: Ophthalmic Res 1997;29:103–109
          DOI: 10.1159/000268003
          PubMed ID: 9154536
          SO-VID: f1e2252c-bcbd-45d7-a758-7e46c882a8b3
          Copyright © © 1997 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 30 July 1996
          Date accepted : 31 October 1996
          Page count
          Pages: 7
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Brush cytology,Flow cytometry,Conjunctival epithelial cells,Integrin,Adhesion molecule
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Brush cytology, Flow cytometry, Conjunctival epithelial cells, Integrin, Adhesion molecule

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