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Abstract
Urinary tract infection (UTI) in an infant may be the first indication of an underlying
renal disorder. Early recognition and initiation of adequate therapy for UTI is important
to reduce the risk of long-term renal scarring. Ampicillin and gentamicin are traditionally
the empiric treatment of choice; however, local antibiotic resistance patterns should
be considered. Maternal antibiotics during pregnancy also increase the risk of resistant
pathogens during neonatal UTI. Long-term management after the first UTI in infants
remains controversial because of lack of specific studies in this age group and the
risk-benefit issues for antibiotic prophylaxis between reduced recurrent disease and
emergent antibiotic resistance.