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      Assessment of HER2 gene status in breast carcinomas with polysomy of chromosome 17.

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          Abstract

          The current study was performed to determine the impact of polysomy 17 on the interpretation of HER2 testing of invasive breast carcinomas using fluorescent in situ hybridization methods. Current American Society of Clinical Oncology/College of American Pathologists guidelines define HER2-positive tumors as those with >6 HER2 genes per nucleus or those with HER2/CEP17 (chromosome 17) ratio >2.2. These guidelines are potentially contradictory in tumors with polysomy of chromosome 17.

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          Author and article information

          Journal
          Cancer
          Cancer
          Wiley
          0008-543X
          0008-543X
          Jan 01 2011
          : 117
          : 1
          Affiliations
          [1 ] Department of Pathology, Creighton University School of Medicine, Omaha, Nebraska 68131, USA.
          Article
          10.1002/cncr.25580
          20803611
          f1fc911c-2a3c-4a71-b1d2-f174e8f8e0bf
          © 2010 American Cancer Society.
          History

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