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Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump.

Author(s): Grant D Geske, Margrith Mattmann, T. Hatano, Simon Blackwell, Dora Y L Chan, H Bian, Hiroaki Suga, Jun Igarashi, K Chua, Edward C. T. H. Tan

Publication date: 2007-05-31

Journal: Journal of Bacteriology

Keywords: 4-Butyrolactone, analogs & derivatives, metabolism, Bacterial Outer Membrane Proteins, genetics, Burkholderia pseudomallei, physiology, Chromatography, High Pressure Liquid, Gene Expression Regulation, Bacterial, Homoserine, Lactones, Mutation, Quorum Sensing

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Abstract

The Burkholderia pseudomallei KHW quorum-sensing systems produced N-octanoyl-homoserine lactone, N-decanoyl-homoserine lactone, N-(3-hydroxy)-octanoyl-homoserine lactone, N-(3-hydroxy)-decanoyl-homoserine lactone, N-(3-oxo)-decanoyl-homoserine lactone, and N-(3-oxo)-tetradecanoyl-homoserine lactone. The extracellular secretion of these acyl-homoserine lactones is dependent absolutely on the function of the B. pseudomallei BpeAB-OprB efflux pump.

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PubMed ID:: 17384185

PMC ID:: 1913402

DOI:: 10.1128/JB.00003-07

ScienceOpen disciplines: Chemistry

Keywords: 4-Butyrolactone,analogs & derivatives,metabolism,Bacterial Outer Membrane Proteins,genetics,Burkholderia pseudomallei,physiology,Chromatography, High Pressure Liquid,Gene Expression Regulation, Bacterial,Homoserine,Lactones,Mutation,Quorum Sensing

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ScienceOpen disciplines: Chemistry

Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump.

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