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      Wnt/β-catenin signaling and disease.

      Cell
      Elsevier BV

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          Abstract

          The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

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          Journal
          10.1016/j.cell.2012.05.012
          22682243

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