Fate by RNA methylation: m ⁶A steers stem cell pluripotency

Abstract

The N ⁶-methyladenosine (m ⁶A) modification of mRNA has a crucial function in regulating pluripotency in murine stem cells: it facilitates resolution of naïve pluripotency towards differentiation.

Contributors

Boxuan Simen Zhao: [e-mail]

Chuan He: [e-mail]

Journal

Journal ID (nlm-ta): Genome Biol

Title: Genome Biology

Publisher: BioMed Central (London )

ISSN (Print): 1465-6906

ISSN (Electronic): 1465-6914

Publication date (Electronic): 22 February 2015

Publication date PMC-release: 22 February 2015

Publication date (Print): 2015

Volume: 16

Issue: 1

Affiliations

[ ]Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637 USA

[ ]Howard Hughes Medical Institute, The University of Chicago, 929 East 57 Street, Chicago, IL 60637 USA

Article

Publisher ID: 609

DOI: 10.1186/s13059-015-0609-1

PMC ID: 4336730

Copyright statement: © Zhao and He; licensee BioMed Central. 2015

License:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Categories

Subject: Research Highlight

Custom metadata

issue-copyright-statement © The Author(s) 2015