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Synthesis and study of the antimalarial cardamom peroxide
June 2018
June 2018
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Abstract
<p class="first" id="P1">A full account of our previously disclosed synthesis of the
monoterpene dimer cardamom
peroxide is reported. Inspired by hypotheses regarding the potential biosynthetic
origins of this natural product, several unproductive routes are also reported. The
chemical reactivity of this structurally unique metabolite in the presence of iron(II)
sources is also reported as is its antimalarial activity against
<i>Plasmodium falciparum</i> clinical isolates from several Cambodian provinces.
</p><p id="P2">
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