54
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Recommendations for planning pilot studies in clinical and translational research.

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Advances in clinical and translation science are facilitated by building on prior knowledge gained through experimentation and observation. In the context of drug development, preclinical studies are followed by a progression of phase I through phase IV clinical trials. At each step, the study design and statistical strategies are framed around research questions that are prerequisites for the next phase. In other types of biomedical research, pilot studies are used for gathering preliminary support for the next research step. However, the phrase "pilot study" is liberally applied to projects with little or no funding, characteristic of studies with poorly developed research proposals, and usually conducted with no detailed thought of the subsequent study. In this article, we present a rigorous definition of a pilot study, offer recommendations for the design, analysis and sample size justification of pilot studies in clinical and translational research, and emphasize the important role that well-designed pilot studies play in the advancement of science and scientific careers.

          Related collections

          Author and article information

          Journal
          Clin Transl Sci
          Clinical and translational science
          Wiley
          1752-8062
          1752-8054
          Oct 2011
          : 4
          : 5
          Affiliations
          [1 ] University of Pittsburgh, Pittsburgh, Pennsylvania, USA. moorecg@upmc.edu
          Article
          NIHMS324495
          10.1111/j.1752-8062.2011.00347.x
          3203750
          22029804
          f23701d5-3ccc-4fb4-85db-88084f2b97f5
          © 2011 Wiley Periodicals, Inc.
          History

          Comments

          Comment on this article

          scite_

          Similar content305

          Cited by203