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      Gastrointestinal Microbiome Modulator Improves Glucose Tolerance in Overweight and Obese Subjects: A Randomized Controlled Pilot Trial

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          Abstract

          Objective

          The objective of this study was to examine the effects of a gastrointestinal microbiome modulator (GIMM) containing inulin, β-glucan, blueberry anthocyanins, and blueberry polyphenols on metabolic parameters, fecal markers of gut microbiota, and satiety.

          Design and Methods

          Thirty overweight or obese individuals aged 18 to 70 years, were enrolled in a randomized controlled trial. Participants consumed the test product or placebo daily for four weeks. Stool samples were collected and blood was drawn at baseline and week four for assessments of gut microbiota, satiety hormones, glucose control, and lipid measures. Subjective satiety was assessed weekly. Linear models were used to compare differences from baseline to week four.

          Results

          GIMM consumption improved blood glucose tolerance (p = 0.008), and increased satiety (p = 0.03). There were no statistically significant differences in insulin sensitivity, fecal markers of gut microbiota, plasma satiety hormones, or serum lipid concentrations between the groups. However, plasma satiety hormones and fecal short chain fatty acid concentrations increased in the test group compared to the placebo.

          Conclusions

          GIMM consumption for four weeks, increases satiety, and improves glucose tolerance possibly through insulin-independent pathways.

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          Author and article information

          Contributors
          Journal
          9204583
          1282
          J Diabetes Complications
          J. Diabetes Complicat.
          Journal of diabetes and its complications
          1056-8727
          1873-460X
          5 September 2015
          03 September 2015
          Nov-Dec 2015
          01 November 2016
          : 29
          : 8
          : 1272-1276
          Affiliations
          [a ]Pennington Biomedical Research Center, Louisiana State University System, 6400, Perkins Road Baton Rouge, LA 70808, USA
          [b ]School of Nutrition and Food Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
          [c ]MicroBiome Therapeutics LLC, 1316 Jefferson Ave., New Orleans, LA 70115, USA
          Author notes
          Corresponding Author: Frank L. Greenway M.D., Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, Phone: (225) 763-2576, Fax: (225) 763-3022, Frank.Greenway@ 123456pbrc.edu
          Article
          PMC4656110 PMC4656110 4656110 nihpa720612
          10.1016/j.jdiacomp.2015.08.023
          4656110
          26424589
          f24b3615-ba82-4652-bd3a-6954ea2b12fd
          History
          Categories
          Article

          Glucose Tolerance,Blueberry,Inulin,β-glucan,Microbiota,Satiety
          Glucose Tolerance, Blueberry, Inulin, β-glucan, Microbiota, Satiety

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