The purpose of the present study was to identify one or more aerodynamic or electroglottographic measures that distinguish among voicing patterns that are clinically relevant for nodule pathogenesis and regression: a presumably pathogenic pattern (pressed voice), a neutral pattern (normal voice), and two presumably therapeutic patterns (resonant voice and breathy voice). Trained subjects with normal voices produced several tokens of each voice type on sustained vowels /a/, /i/, and /u/. For each token, maximum flow declination rate, alternating current flow, and minimum flow were obtained from inverse-filtered airflow signals, and closed quotient and closing time were obtained from electroglottographic signals. The results indicate that for /a/ and /i/ (but not for /u/), the closed quotient provides a sensitive tool for distinguishing the voice types in physiologically interpretable directions. Further, post-hoc analyses confirmed a direct relationship between the closed quotient and videoscopic ratings of laryngeal adduction, which previous work links to nodule pathogenesis and regression.