1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      PTEN.

      Annual review of biochemistry

      Animals, Cell Cycle, Cell Movement, Cell Nucleus, metabolism, Cell Polarity, Cell Proliferation, Cell Survival, Enzyme Activation, Gene Expression Regulation, Enzymologic, Humans, Lipids, chemistry, Neoplasms, Oxygen, PTEN Phosphohydrolase, physiology, Phosphorylation, Prognosis, Protein Interaction Mapping, Protein Multimerization, Protein Structure, Tertiary, Substrate Specificity, Ubiquitin

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The importance of PTEN in cellular function is underscored by the frequency of its deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid phosphatase activity, which opposes PI3K/AKT activation. As such, PTEN regulates many cellular processes, including proliferation, survival, energy metabolism, cellular architecture, and motility. More than a decade of research has expanded our knowledge about how PTEN is controlled at the transcriptional level as well as by numerous posttranscriptional modifications that regulate its enzymatic activity, protein stability, and cellular location. Although the role of PTEN in cancers has long been appreciated, it is also emerging as an important factor in other diseases, such as diabetes and autism spectrum disorders. Our understanding of PTEN function and regulation will hopefully translate into improved prognosis and treatment for patients suffering from these ailments.

          Related collections

          Author and article information

          Journal
          24905788
          10.1146/annurev-biochem-082411-113907

          Comments

          Comment on this article