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      Do the dissociative side effects of ketamine mediate its antidepressant effects?

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          Abstract

          The N-methyl-d-aspartate receptor antagonist ketamine has rapid antidepressant effects in major depression. Psychotomimetic symptoms, dissociation and hemodynamic changes are known side effects of ketamine, but it is unclear if these side effects relate to its antidepressant efficacy.

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          Author and article information

          Journal
          Journal of Affective Disorders
          Journal of Affective Disorders
          Elsevier BV
          01650327
          April 2014
          April 2014
          : 159
          : 56-61
          Article
          10.1016/j.jad.2014.02.017
          24679390
          f25147e8-1798-4908-96a0-d58b4dff30fe
          © 2014
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