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      Chorioamnionitis Following Vaccination in the Vaccine Adverse Event Reporting System

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          Abstract

          Background:

          In October 2012, the Advisory Committee on Immunization Practices (ACIP) recommended a dose of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) during each pregnancy, irrespective of the patient’s prior history of receiving Tdap. A retrospective cohort study to assess the safety of Tdap vaccination in pregnant women in two Vaccine Safety Datalink (VSD) sites during 2010-2012 found a small but statistically significant increased risk of chorioamnionitis.

          Objective:

          We conducted a review of the VAERS database to describe reports of chorioamnionitis following receipt of any vaccines.

          Methods:

          We searched the VAERS database for reports of chorioamnionitis after any vaccine in the United States during the period from July 1, 1990 through February 2, 2014.

          Results:

          VAERS received 31 reports of chorioamnionitis out of 3,389 pregnancy reports. The three most common vaccines administered were 2009 H1N1 inactivated influenza, quadrivalent human papillomavirus (HPV4), and Tdap vaccines in 32%, 29% and 26% of reports, respectively. Fifty-eight percent of reports had at least one risk factor for chorioamnionitis. Chorioamnionitis was identified in 3 reports of spontaneous abortions and 6 stillbirths, 6 reports of preterm birth (two of whom died) and 16 reports of term birth; maternal outcomes included two reports of postpartum hemorrhage and one report of maternal admission to the intensive care unit. No maternal deaths were reported.

          Conclusion:

          Chorioamnionitis was found to be uncommonly reported, representing 1% of pregnancy reports to VAERS. A majority of reports had at least one risk factor for chorioamnionitis.

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          Author and article information

          Journal
          8406899
          7945
          Vaccine
          Vaccine
          Vaccine
          0264-410X
          1873-2518
          25 April 2019
          11 May 2015
          17 June 2015
          04 May 2019
          : 33
          : 27
          : 3110-3113
          Affiliations
          Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Zoonotic and Emerging Infectious Diseases (NCZEID), Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia 30333
          Author notes
          [*]

          These authors contributed equally to this work

          Article
          PMC6500452 PMC6500452 6500452 hhspa1025263
          10.1016/j.vaccine.2015.04.097
          6500452
          25976546
          f25f3be1-dae0-4feb-82a8-efb5281d7527
          History
          Categories
          Article

          pregnancy,chorioamnionitis,adverse event,2009 H1N1 inactivated influenza vaccine,HPV4,vaccine safety,Tdap,surveillance

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