Analysis of family cluster outbreak of coronavirus disease 2019 caused by nosocomial infection

Abstract

Objective A coronavirus disease 2019 (COVID-19) cluster epidemic in a hospital infection was investigated for infection characteristics, and providing scientific basis to prevention and control of COVID-19.

Methods Descriptive epidemiological method was used to analyze the characteristics of the COVID-19 clustering epidemic in Weifang City. The respiratory tract specimens and the deep sputum solution were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid by real-time fluorescent quantitative RT-PCR. The confirmed cases and asymptomatic infectious persons were diagnosed by the National Health and Health Committee’s New Diagnosis and Treatment Plan for the Coronavirus Infection (Fourth Edition).

Results The 8 second generation cases and 7 third generation cases, involving 4 family clusters were infected for the reason that the first generation case concealed the travel history. And infection of medical staff was not occurred.

Conclusion It is very important for the diagnosis of patients to inquire about the detailed travel history and contact history. Personal protection of medical staff can effectively reduce the incidence of the infection. Close contact among family members is an important risk factor for the occurrence of the epidemic.

Abstract

摘要： 目的 调查分析一起院内感染为主的新型冠状病毒肺炎 (COVID-19) 多家庭聚集疫情特点, 为聚集性疫情的防控提供科学依据。 方法 应用描述流行病学方法分析潍坊市某新冠肺炎聚集疫情特点, 采用实时荧光定量RTPCR法对采集的呼吸道标本、深咳痰液等进行新型冠状病毒(SARS-CoV-2)核酸检测, 确诊病例和无症状感染者判定按照《国家卫生健康委新型冠状病毒感染的肺炎诊疗方案 (试行第四版) 》要求进行。 结果 首代病例就诊时隐瞒外出旅行史, 导致由院内感染和家庭接触引发的8个二代病例和7个三代病例发生, 涉及4个家庭内聚集, 没有引起医护人员的感染或发病。 结论 详细询问病人外出旅行史和其他接触史对病例的诊断至关重要, 做好医护人员个人防护可有效降低院内感染的发生, 家庭成员间的密切接触传播是聚集疫情发生的重要危险因素。