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Calorie restriction increases life span in many organisms, including the budding yeast
Saccharomyces cerevisiae. From a large-scale analysis of 564 single-gene-deletion
strains of yeast, we identified 10 gene deletions that increase replicative life span.
Six of these correspond to genes encoding components of the nutrient-responsive TOR
and Sch9 pathways. Calorie restriction of tor1D or sch9D cells failed to further increase
life span and, like calorie restriction, deletion of either SCH9 or TOR1 increased
life span independent of the Sir2 histone deacetylase. We propose that the TOR and
Sch9 kinases define a primary conduit through which excess nutrient intake limits
longevity in yeast.