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      Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.

      Bioorganic & Medicinal Chemistry Letters
      Animals, Anti-Inflammatory Agents, pharmacology, Atherosclerosis, drug therapy, Catechols, Cell Line, Flavonoids, Humans, Mice, Moraceae, Xanthones

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          Abstract

          The catecholic xanthones and flavonoids 1-13 were isolated from the root bark of Cudrania tricuspidata. Compounds 1 and 3-8 exhibited significant antioxidant activity against low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance (TBARS) assay. Among them, prenylated flavonoids 10-12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1.

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          Author and article information

          Journal
          16919944
          10.1016/j.bmcl.2006.08.032

          Chemistry
          Animals,Anti-Inflammatory Agents,pharmacology,Atherosclerosis,drug therapy,Catechols,Cell Line,Flavonoids,Humans,Mice,Moraceae,Xanthones

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