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Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial
Kohei Shitara ,
Mustafa Özgüroğlu ,
Yung-Jue Bang ,
Maria Di Bartolomeo ,
Mario Mandalà ,
Min-Hee Ryu ,
Lorenzo Fornaro ,
Tomasz Olesiński ,
Christian Caglevic ,
Hyun C Chung ,
Kei Muro ,
Eray Goekkurt ,
Wasat Mansoor ,
Raymond S McDermott ,
Einat Shacham-Shmueli ,
Xinqun Chen ,
Carlos Mayo ,
S Peter Kang ,
Atsushi Ohtsu ,
Charles S Fuchs ,
Guillermo Lerzo ,
Juan Manuel O'Connor ,
Guillermo Ariel Mendez ,
James Lynam ,
Niall Tebbutt ,
Mark Wong ,
Andrew Strickland ,
Chris Karapetis ,
David Goldstein ,
Paul Vasey ,
Jean-Luc Van Laethem ,
Eric Van Cutsem ,
Scott Berry ,
Mark Vincent ,
Bettina Muller ,
Felipe Rey ,
Angela Zambrano ,
Joaquin Guerra ,
Merete Krogh ,
Lene Baeksgaard ,
Mette Yilmaz ,
Anneli Elme ,
Andrus Magi ,
Paivi Auvinen ,
Tuomo Alanko ,
Markus Moehler ,
Volker Kunzmann ,
Thomas Seufferlein ,
Peter Thuss-Patience ,
Eray Goekkurt ,
Thomas Hoehler ,
Georg Haag ,
Salah-Eddin Al-Batran ,
Hugo Castro ,
Karla Lopez ,
Mynor Aguilar Vasquez ,
Mario Sandoval ,
Ka On Lam ,
Sinead Cuffe ,
Cathy Kelly ,
Ravit Geva ,
Einat Shacham-Shmueli ,
Ayala Hubert ,
Alex Beny ,
Baruch Brenner ,
Aprile Giuseppe ,
Alfredo Falcone ,
Evaristo Maiello ,
Rodolfo Passalacqua ,
Vincenzo Montesarchio ,
Hiroki Hara ,
Keisho Chin ,
Tomohiro Nishina ,
Yoshito Komatsu ,
Nozumo Machida ,
Shuichi Hironaka ,
Taroh Satoh ,
Takao Tamura ,
Naotaoshi Sugimoto ,
Haruhiko Cho ,
Yashushi Omuro ,
Ken Kato ,
Masahiro Goto ,
Ichinosuke Hyodo ,
Kazuhiro Yoshida ,
Hideo Baba ,
Taito Esaki ,
Junji Furuse ,
Wan Zamaniah Wan Mohammed ,
Carlos Hernandez Hernandez ,
Juan Casas Garcia ,
Adriana Dominguez Andrade ,
Katriona Clarke ,
Geir Hjortland ,
Nils Glenjen ,
Tomasz Kubiatowski ,
Jassem Jacek ,
Marek Wojtukiewicz ,
Sergey Lazarev ,
Yuri Lancukhay ,
Sergey Afanasayev ,
Vladimir Moiseyenko ,
Vladimir Kostorov ,
Svetlana Protsenko ,
Vadim Shirinkin ,
Dina Sakaeva ,
Natalia Fadeeva ,
Wei Peng Yong ,
Chau Hsien Matthew Ng ,
Barbara Robertson ,
Bernardo Rapaport ,
Graham Cohen ,
Lydia Dreosti ,
Paul Ruff ,
Conrad Jacobs ,
Gregory Landers ,
Waldemar Szpak ,
Sang-Young Roh ,
Jeeyun Lee ,
Yeul Hong Kim ,
Yung-Jue Bang ,
Hyun Cheol Chung ,
Min-Hee Ryu ,
Maria Alsina Maqueda ,
Federico Longo Munoz ,
Andres Cervantes Aguilar ,
Enrique Aranda Aguilar ,
Pilar Garcia Alfonso ,
Fernando Rivera ,
Jaime Feliu Batle ,
Roberto Pazo Cid ,
Kun-Huei Yeh ,
Jen-Shi Chen ,
Yee Chao ,
Chia-Jui Yen ,
Mustafa Özgüroğlu ,
Oguz Kara ,
Suayib Yalcin ,
Daniel Hochhauser ,
Ian Chau ,
Al Benson ,
Veena Shankaran ,
Walid Shaib ,
Philip Philip ,
Vivek Sharma ,
Robert Siegel ,
Weijing Sun ,
Zev Wainberg ,
Ben George ,
Andrea Bullock ,
Samuel Myrick ,
Josephine Faruol ,
Richard Siegel ,
Timothy Larson ,
Carlos Becerra ,
Suresh Ratnam ,
Donald A. Richards ,
Stephen L. Riche
June 2018
June 2018
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
<p class="first" id="d3820573e352">Patients with advanced gastric or gastro-oesophageal
junction cancer that progresses
on chemotherapy have poor outcomes. We compared pembrolizumab with paclitaxel in patients
with advanced gastric or gastro-oesophageal junction cancer that progressed on first-line
chemotherapy with a platinum and fluoropyrimidine.
</p>