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Targeting T1 and T2 dual modality enhanced magnetic resonance imaging of tumor vascular endothelial cells based on peptides-conjugated manganese ferrite nanomicelles

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      Abstract

      Tumor angiogenesis plays very important roles for tumorigenesis, tumor development, metastasis, and prognosis. Targeting T 1/T 2 dual modality magnetic resonance (MR) imaging of the tumor vascular endothelial cells (TVECs) with MR molecular probes can greatly improve diagnostic sensitivity and specificity, as well as helping to make an early diagnosis of tumor at the preclinical stage. In this study, a new T 1 and T 2 dual modality nanoprobe was successfully fabricated. The prepared nanoprobe comprise peptides CL 1555, poly(ε-caprolactone)-block-poly(ethylene glycol) amphiphilic copolymer shell, and dozens of manganese ferrite (MnFe 2O 4) nanoparticle core. The results showed that the hydrophobic MnFe 2O 4 nanoparticles were of uniform spheroidal appearance and narrow size distribution. Due to the self-assembled nanomicelles structure, the prepared probes were of high relaxivity of 281.7 mM −1 s −1, which was much higher than that of MnFe 2O 4 nanoparticles (67.5 mM 1 s −1). After being grafted with the targeted CD105 peptide CL 1555, the nanomicelles can combine TVECs specifically and make the labeled TVECs dark in T 2-weighted MR imaging. With the passage on, the Mn 2+ ions were released from MnFe 2O 4 and the size decreased gradually, making the signal intensity of the second and third passage of labeled TVECs increased in T 1-weighted MR imaging. Our results demonstrate that CL-poly(ethylene glycol)-MnFe 2O 4 can conjugate TVECs and induce dark and bright contrast in MR imaging, and act as a novel molecular probe for T 1- and T 2-enhanced MR imaging of tumor angiogenesis.

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            Author and article information

            Affiliations
            [1 ]Department of Radiology, Xinqiao Hospital, Third Military Medical University, Chongqing, People’s Republic of China
            [2 ]Department of Radiology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, People’s Republic of China
            [3 ]Geosciences Department, University of Wisconsin-Parkside, Kenosha, WI, USA
            Author notes
            Correspondence: Liguang Zou, Department of Radiology, Xinqiao Hospital, Third Military Medical University, No 183, Xinqiao Street, Shapingba District, Chongqing, People’s Republic of China, Tel +86 23 6877 4036, Fax +86 23 6875 5306, Email cqxqyyzlg@ 123456163.com
            Journal
            Int J Nanomedicine
            Int J Nanomedicine
            International Journal of Nanomedicine
            International Journal of Nanomedicine
            Dove Medical Press
            1176-9114
            1178-2013
            2016
            19 August 2016
            : 11
            : 4051-4063
            4998025 10.2147/IJN.S104686 ijn-11-4051
            © 2016 Gong et al. This work is published and licensed by Dove Medical Press Limited

            The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

            Categories
            Original Research

            Molecular medicine

            tumor angio genesis, cl 1555, cd105, tvecs, cl-peg-mnfe2o4

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