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      Deep Learning-Based Correlation Analysis between Spine Surgery Lumbar Facet Joint and Lumbar Disc Herniation Using Magnetic Resonance Images

      1 , 1 , 1 , 1
      Scientific Programming
      Hindawi Limited

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          Abstract

          The research aimed at discussing the analytic function of convolutional neural network (CNN) algorithm-based magnetic resonance images (MRI) in the correlation between lumbar disc herniation (LDH) and angle and irregular variation of joint (IVJ) of lumbar facet-joint (LFJ). First, CNN-based MRI (CNNM) algorithm was constructed, and Markov random field (MRF) and fuzzy C-means (FCM) algorithms were introduced for comparison. Meanwhile, all patients received MRI examination of lumbar, and CNNM algorithm was adopted in MRI images. The results showed that the sensitivity, specificity, accuracy, and precision (98.53%, 93.65%, 99.56%, and 98.74%, respectively) of the CNNM algorithm were all superior to those of MRF algorithm (90.41%, 81.11%, 91.18%, and 91.13%, respectively) and of FCM algorithm (93.14%, 82.86%, 93.23%, and 93.08%, respectively) ( P < 0.05 ). Besides, the lumbar spine angles of L3-L4, L4-L5, and L5-S1 (6.03 ± 1.34°, 7.14 ± 1.18°, and 8.96 ± 3.26°, respectively) in the experimental group was obviously less than those in the control group (6.84 ± 1.15°, 9.85 ± 1.25°, and 17.34 ± 4.79°, respectively) ( P < 0.05 ). In the experimental group, there was irregular mutation of LFJ in 78 cases, while 8 cases suffered from irregular mutation of LFJ in the control group. The proportions of protrusion in L3/4, L4/5, and L5/S1 segments (11 cases, 53 cases, and 14 cases, respectively) was higher than that in the control group (1 case, 5 cases, and 2 cases, respectively) ( P < 0.05 ). In short, the constructed CNNM algorithm had excellent performance in diagnosing lumbar MRI images and had clinical research and promotion value. Moreover, the IVJ of patients with LDH was notably increased, most of the physiological angle of the lumbar spine changed, and facet joint was correlated with the occurrence of LDH.

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          Response assessment using 68 Ga-PSMA ligand PET in patients undergoing 177 Lu-PSMA radioligand therapy for metastatic castration-resistant prostate cancer

          Purpose The first aim of this study was to evaluate 68Ga-PSMAHBED-CC conjugate 11 positron emission tomography (PSMA PET) parameters for assessment of response to 177Lu-PSMA-617 radioligand therapy (RLT) in patients with metastatic castration-resistant prostate cancer (mCRPC). The second aim was to investigate factors associated with overall survival (OS). Methods We retrospectively assessed mean standardized uptake values (SUVmean) and total tumor volumes (TTV) on PSMA PET in 38 of 55 mCRPC patients before and after RLT. PSA testing and PSMA PET/CT(MRI) imaging were performed during the 8 weeks before and the 6 weeks after RLT. PSMA PET and CT(MRI) images were reviewed separately according to the modified PET Response Criteria in Solid Tumors (mPERCIST) and RECIST1.1. The results were compared with PSA responses. Associations between OS and the RECIST evaluation and changes in SUVmean, TTV, and PSA, CRP, LDH, hemoglobin and ALP levels were determined in a univariable survival analysis. Results The median PSA level at the time of pretherapy PSMA PET/CT(MRI) was 60.8 ng/ml (IQR 15.4, 264.2 ng/ml). After RLT the median PSA level decreased by 44%, TTV by 45.1%, SUVmean by 25.8% and RECIST by 11.3%. A PSA response was seen in 18 patients (47.4%), stable disease in 12 (31.6%) and progressive disease in 8 (21.1%). Contrary to the changes in SUVmean and the RECIST evaluation, the change in TTV was significantly associated with PSA response (p = 0.15, p = 0.58, and p < 0.001, respectively). After a median follow-up of 17 months (IQR 8.0, 24.2 months), 11 patients (28.9%) had died of their prostate cancer. The changes in both TTV and PSA levels were associated with OS (HR 1.001, 95% CI 1–1.003, p = 0.04, and HR 1.004, 95% CI 1.001–1.008, p = 0.01, respectively), while the changes in SUVmean and the RECIST evaluation were not. The pre-therapy CRP level was also associated with OS (HR 1.07, 95% CI 1.009–1.14, p = 0.02). Conclusion TTV on PSMA PET seems to be a reliable parameter for response assessment in mCRPC patients undergoing RLT and might overcome the limitations of RECIST in prostate cancer. Furthermore, the change in TTV was significantly associated with OS in our cohort.
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            Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

            SUMMARY The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to determine whether LDH is a feasible drug target are lacking. We describe an LDHi with potent, on-target, in vivo activity. Using hyperpolarized magnetic resonance spectroscopic imaging (HP-MRSI), we demonstrate in vivo LDH inhibition in two glycolytic cancer models, MIA PaCa-2 and HT29, and we correlate depth and duration of LDH inhibition with direct anti-tumor activity. HP-MRSI also reveals a metabolic rewiring that occurs in vivo within 30 min of LDH inhibition, wherein pyruvate in a tumor is redirected toward mitochondrial metabolism. Using HP-MRSI, we show that inhibition of mitochondrial complex 1 rapidly redirects tumor pyruvate toward lactate. Inhibition of both mitochondrial complex 1 and LDH suppresses metabolic plasticity, causing metabolic quiescence in vitro and tumor growth inhibition in vivo.
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              Neural substrates of cognitive reserve in Alzheimer's disease spectrum and normal aging

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                Author and article information

                Contributors
                Journal
                Scientific Programming
                Scientific Programming
                Hindawi Limited
                1875-919X
                1058-9244
                December 6 2021
                December 6 2021
                : 2021
                : 1-7
                Affiliations
                [1 ]Department of Orthopedics, Changhai Hospital affiliated to Naval Medical University, Shanghai 200433, China
                Article
                10.1155/2021/9623991
                f28e5ee7-c389-4125-9a0e-4e093a8d4739
                © 2021

                https://creativecommons.org/licenses/by/4.0/

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