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      Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

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      Cell
      Elsevier BV

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          Most cited references143

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          Integrins: a family of cell surface receptors.

          R O Hynes (1987)
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            The immunoglobulin superfamily--domains for cell surface recognition.

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              VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site.

              Cytokine-activated human endothelial cells express vascular cell adhesion molecule-1 (VCAM-1), which binds lymphocytes. We now identify the integrin VLA-4 as a receptor for VCAM-1 because VLA-4 surface expression on K-562 cells (following transfection of the VLA alpha 4 subunit cDNA) resulted in specific cell adhesion to VCAM-1, and anti-VLA-4 antibodies completely inhibited VCAM-1-dependent cell-cell attachment. In addition, VLA-4 expression allowed K-562 cells to attach to the heparin II binding region (FN-40) of fibronectin. However, VLA-4/VCAM-1 and VLA-4/FN-40 interactions are readily distinguishable: only the former was inhibited by the anti-VLA-4 monoclonal antibody HP1/3, and only the latter was inhibited by soluble FN-40. The VCAM-1/VLA-4 ligand-receptor pair may play a major role in the recruitment of mononuclear leukocytes to inflammatory sites in vivo.
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                Author and article information

                Journal
                Cell
                Cell
                Elsevier BV
                00928674
                January 1992
                January 1992
                : 68
                : 2
                : 303-322
                Article
                10.1016/0092-8674(92)90472-O
                1733501
                f295a702-d123-44bc-b23c-a8356080d09c
                © 1992

                https://www.elsevier.com/tdm/userlicense/1.0/

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