22
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1.

      Nature
      Animals, Base Sequence, Blood Pressure, genetics, physiology, Branchial Region, abnormalities, embryology, DNA Primers, Embryonic and Fetal Development, Endothelins, deficiency, Female, Heterozygote, Homozygote, Male, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Molecular Sequence Data, Organ Culture Techniques, Respiratory Insufficiency, Skull, Stem Cells

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient in ET-1. These ET-1-/- homozygous mice die of respiratory failure at birth and have morphological abnormalities of the pharyngeal-arch-derived craniofacial tissues and organs. ET-1+/- heterozygous mice, which produce lower levels of ET-1 than wild-type mice, develop elevated blood pressure. These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis.

          Related collections

          Author and article information

          Comments

          Comment on this article