The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation.

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Abstract

Signal transduction and kinomics have been rapidly expanding areas of investigation within the malaria research field. Here, we provide an overview of phosphosignalling pathways that operate in all stages of the Plasmodium life cycle. We review signalling pathways in the parasite itself, in the cells it invades, and in other cells of the vertebrate host with which it interacts. We also discuss the potential of these pathways as novel targets for antimalarial intervention.

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Journal

Journal ID (iso-abbrev): Mol. Biochem. Parasitol.

Title: Molecular and biochemical parasitology

Publisher: Elsevier BV

ISSN (Electronic): 1872-9428

ISSN (Print): 0166-6851

Publication date (Electronic): Jul 2016

Volume: 208

Issue: 1

Affiliations

[1 ] Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria 3800, Australia.

[2 ] Burnet Institute, Melbourne, Victoria 3004, Australia; The University of Melbourne, Department of Medicine, Melbourne, Victoria 3010, Australia; Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Victoria 3010, Australia.

[3 ] Vascular Immunology Unit, Department of Pathology, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2050, Australia.

[4 ] Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria 3800, Australia. Electronic address: christian.doerig@monash.edu.

Article

Publisher Item ID: S0166-6851(16)30057-3

DOI: 10.1016/j.molbiopara.2016.05.006

PubMed ID: 27211241

SO-VID: f2b237a4-edf1-4331-89fe-5fbfa663615c

History

Keywords: Signalling,Plasmodium,Protein kinase,Protein phosphatase,Malaria,Phosphorylation

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Keywords: Signalling, Plasmodium, Protein kinase, Protein phosphatase, Malaria, Phosphorylation

The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation.

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Malaria vaccine development

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