Blog
About

208
views
0
recommends
+1 Recommend
0 collections
    16
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.

      Nature genetics

      Transcription Factors, Animals, RNA, Messenger, Oxidative Phosphorylation, Oligonucleotide Array Sequence Analysis, physiology, Myoblasts, drug effects, Muscle, Skeletal, Mice, Male, Insulin, Humans, Glucose Tolerance Test, metabolism, Glucose, Gene Expression Profiling, Down-Regulation, genetics, Diabetes Mellitus, Type 2, Cells, Cultured, pharmacology

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments.

          Related collections

          Author and article information

          Journal
          10.1038/ng1180
          12808457

          Comments

          Comment on this article