Residual Force Enhancement Following Eccentric Contractions: A New Mechanism Involving Titin.

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Abstract

Eccentric muscle properties are not well characterized by the current paradigm of the molecular mechanism of contraction: the cross-bridge theory. Findings of force contributions by passive structural elements a decade ago paved the way for a new theory. Here, we present experimental evidence and theoretical support for the idea that the structural protein titin contributes to active force production, thereby explaining many of the unresolved properties of eccentric muscle contraction.

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Journal

Journal ID (iso-abbrev): Physiology (Bethesda)

Title: Physiology (Bethesda, Md.)

ISSN (Electronic): 1548-9221

ISSN (Print): 1548-9221

Publication date (Electronic): Jul 2016

Volume: 31

Issue: 4

Affiliations

[1 ] University of Calgary Human Performance Laboratory, Calgary, Alberta, Canada wherzog@ucalgary.ca.

[2 ] University of Calgary Human Performance Laboratory, Calgary, Alberta, Canada.

Article

Publisher Item ID: 31/4/300

DOI: 10.1152/physiol.00049.2014

PubMed ID: 27252165

SO-VID: f2c3f407-8418-4edd-99d0-365667f36a29

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