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      Membranous Glomerulonephritis in a Patient with Unilateral Renal Agenesis



      S. Karger AG

      Membranous glomerulonephritis, Unilateral renal agenesis

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          Secondary membranous glomerulonephritis (MGN) is usually caused by drugs or systemic disorders that produce circulating immune complexes. However, some disorders that did not seem to form circulating immune complexes have been listed as underlying diseases of secondary MGN. The case of a 13-year-old boy with MGN and unilateral renal agenesis is presented. Renal histology showed segmental MGN with mesangial proliferation and mesangial electron-dense deposits, and no other underlying disorder except for unilateral renal agenesis. Patients with MGN, who have histological findings suggesting secondary MGN and no underlying disorder distinctly causing formation of circulating immune complexes, should not be defined as having idiopathic or secondary forms, but as having a ‘cryptogenic’ form.

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          Focal glomerulosclerosis and proteinuria in patients with solitary kidneys.

          We have studied ten normotensive patients (nine male and one female, aged between 28 and 51 years) who each had a solitary functioning kidney and proteinuria. Six had undergone unilateral nephrectomy, and four unilateral renal agenesis. In each case, intravenous pyelography revealed only one functioning kidney with compensating hypertrophy. Mild to moderate chronic renal failure was present in six, and microhematuria in two. Proteinuria ranged from 1.10 to 4.10 g/24 hr, being in the nephrotic range in three patients. In seven patients, a renal biopsy showed focal glomerulosclerosis. Immunofluorescence studies demonstrated granular deposits of IgM in three and C3 in six cases, over the sclerotic areas. We suggest that the appearance of proteinuria and focal glomerulosclerosis in a patient with a solitary kidney could be due to chronic glomerular hyperfiltration.

            Author and article information

            S. Karger AG
            May 2002
            02 May 2002
            : 91
            : 1
            : 159-161
            Department of Pediatrics, Niigata City General Hospital, Niigata, Japan
            57619 Nephron 2002;91:159–161
            © 2002 S. Karger AG, Basel

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            Figures: 1, References: 12, Pages: 3
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            Short Communication

            Cardiovascular Medicine, Nephrology

            Unilateral renal agenesis, Membranous glomerulonephritis


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