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      Causes of delay in proper treatment of patients with undescended testis

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          Abstract

          Background: Undescended testis (UDT) is the most common endocrine disorder in male children. Delayed diagnosis and treatment of UDT lead to complications such as infertility, malignancy and testis rotation.

          Objective: The aim of this study was to evaluate the causes of delay in proper treatment of patients with undescended testis in our population.

          Materials and Methods: An observational, descriptive, cross sectional study of 143 male patients, who applied to Shahid Sadoughi University Hospitals for orchiopexy operation was performed. The maximum recommended age for orchiopexy was 18 months.

          Results: The mean age at referral was 5.34 years. Only 44 (30.8%) cases were operated on before the age of 18 months. The most common reasons of delay in treatment were absence of early diagnose (42.5%), parent's unawareness of surgery necessity and its complications associated (33.7%) and parent's disregard (23.5%). Only 19.6% of patients were diagnosed at born in the hospital. 49% of parents had the correct information for proper operation age and 40.6% of them had enough information about necessity of surgery and side effects of disease. Parent’s literacy, place of living and type of cryptorchidism had no significant relation with delay diagnosis (p> 0.05).

          Conclusion: These results revealed that late diagnosis by physician and lack of insight of parents are the main reasons in delayed diagnosis and treatment of UDT. Therefore, education of parents and careful physical examination of the babies at birth and regular follow-up until 18 months can prevent the delay in diagnosis.

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          Most cited references34

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          The epidemiology of congenital cryptorchidism, testicular ascent and orchiopexy.

          The frequency, significance and possible etiology of testicular ascent (acquired cryptorchidism) are characterized in light of the known incidence and natural history of congenital cryptorchidism, and data provided by longitudinal and epidemiological studies of ascended testes and orchiopexy rates. We comprehensively reviewed the literature addressing the epidemiology of congenital and acquired cryptorchidism and orchiopexy. The incidence of congenital cryptorchidism in full-term males at birth (2% to 4%) and at age 1 year (approximately 1%) has not increased in the last few decades. The risk of ascent may be as high as 50% in cases where 1 testis is significantly retractile. Ascended testes are typically unilateral (77%), identified in mid childhood and located distal to the inguinal canal (77%). Ascended and significantly retractile testes may be prone to the same germ cell maldevelopment seen in congenital cryptorchidism. Cumulative orchiopexy rates in defined populations are 2% to 4%, and mean age at orchiopexy remains higher than expected (greater than 4 years), despite a long held standard of care that includes recommendation for surgery by age 2. These data suggest that cryptorchidism may be acquired in a significant subset of cases. With close monitoring of young boys spontaneous ascent of testes from a scrotal to a suprascrotal position may be observed with time, due to either true or apparent testicular ascent, with possible adverse effects on germ cell development and fertility potential. Patients with significant testicular retractility appear to be at highest risk for acquired cryptorchidism, and should be followed closely at yearly intervals until puberty.
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            Cryptorchidism: classification, prevalence and long-term consequences.

            Undescended testis is a common finding in boys, and the majority of cases have no discernible aetiology. There are unexplained geographical differences and temporal trends in its prevalence. Cryptorchidism, especially bilateral, is associated with impaired spermatogenesis and endocrine function and increases the risk of testicular cancer. There is an urgent need to identify factors that adversely affect testicular development and optimize treatment. Cryptorchidism may reflect a primary testicular maldevelopment with long-term consequences.
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              Epidemiology and pathogenesis of cryptorchidism.

              Prospective clinical studies have shown that the prevalence of cryptorchidism among boys with birth weight > or =2500 g has increased in UK from 2.7 to 4.1% between the 1950s and the 1980s and in Denmark from 1.8 to 8.4% between the 1950s and the 1990s. In similar studies performed in different countries during the last two decades the figures have varied from 2.1 to 8.4%. Due to spontaneous descent of the testes lower figures, i.e. between 0.9 and 1.8% have been described at 3 months. Acquired cryptorchidism contributes to the increase in the rate of cryptorchidism in school-aged children. Testicular descent occurs in two phases. During the first phase, before midgestation, testis remains anchored to the inguinal area by insulin like hormone 3 (INSL3)-driven development of the gubernaculum. The second inguinoscrotal phase is dependent on testicular androgens and it is usually completed by the time of birth. Mutations of specific genes have rarely been reported in cryptorchidism. However, several risk factors for cryptorchidism, such as preterm birth and low birth weight, have been described. Environmental factors may also have a role in the etiology of cryptorchidism. Future studies on the gene-environment interaction will give new insights to the pathogenesis of cryptorchidism.
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                Author and article information

                Journal
                Iran J Reprod Med
                Iran J Reprod Med
                IJRM
                Iranian Journal of Reproductive Medicine
                Research and Clinical Center for Infertility (Yazd, Iran )
                1680-6433
                2008-2177
                Winter 2011
                : 9
                : 1
                : 37-40
                Affiliations
                [1 ]Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
                [2 ]Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
                Author notes
                Corresponding Author: Seyyed Mostafa Shiryazdi, Department of Surgery, Shahid Sadoughi Hospital, Ebne Sina Blvd, Shahid Ghandi Blvd, Safaeeie, Yazd, Iran. Email: smshiryazdi@ssu.ac.ir
                Article
                ijrm-9-037
                4212144
                f2e3d59a-6317-4a80-a3d4-20c51d01baaf

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License, ( http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 26 April 2010
                : 3 October 2010
                Categories
                Original Article

                delayed diagnosis,undescended testis,orchiopexy,infant
                delayed diagnosis, undescended testis, orchiopexy, infant

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