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      Nucleosome positioning and gene regulation: advances through genomics.

      1 ,
      Nature reviews. Genetics
      Springer Science and Business Media LLC

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          Abstract

          Knowing the precise locations of nucleosomes in a genome is key to understanding how genes are regulated. Recent 'next generation' ChIP-chip and ChIP-Seq technologies have accelerated our understanding of the basic principles of chromatin organization. Here we discuss what high-resolution genome-wide maps of nucleosome positions have taught us about how nucleosome positioning demarcates promoter regions and transcriptional start sites, and how the composition and structure of promoter nucleosomes facilitate or inhibit transcription. A detailed picture is starting to emerge of how diverse factors, including underlying DNA sequences and chromatin remodelling complexes, influence nucleosome positioning.

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          Author and article information

          Journal
          Nat Rev Genet
          Nature reviews. Genetics
          Springer Science and Business Media LLC
          1471-0064
          1471-0056
          Mar 2009
          : 10
          : 3
          Affiliations
          [1 ] Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
          Article
          nrg2522 NIHMS782437
          10.1038/nrg2522
          4860946
          19204718
          f2eb28fe-bce9-45fa-b4ed-eae091ad4280
          History

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