Variants associated with autoimmune Type 1 diabetes in Japanese children: implications for age-specific effects of cis-regulatory haplotypes at 17q12-q21.

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Abstract

The aim of this study was to clarify the significance of previously reported susceptibility variants in the development of autoimmune Type 1 diabetes in non-white children. Tested variants included rs2290400, which has been linked to Type 1 diabetes only in one study on white people. Haplotypes at 17q12-q21 encompassing rs2290400 are known to determine the susceptibility of early-onset asthma by affecting the expression of flanking genes.

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Author and article information

Journal

Journal ID (iso-abbrev): Diabet Med

Title: Diabetic medicine : a journal of the British Diabetic Association

Publisher: Wiley

ISSN (Electronic): 1464-5491

ISSN (Print): 0742-3071

Publication date (Electronic): December 2016

Volume: 33

Issue: 12

Affiliations

[1 ] Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.

[2 ] Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.

[3 ] Department of Pediatrics, Osaka City University Hospital, Osaka, Japan.

[4 ] Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.

[5 ] Department of Pediatrics, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.

[6 ] Department of Clinical Laboratory, Shikoku Medical Center for Children and Adults, Zentsuji, Japan.

[7 ] Department of Pediatrics, Graduate School of Medical Sciences Tokushima University, Tokushima, Japan.

[8 ] Department of Pediatrics, Kyushu University Hospital, Fukuoka, Japan.

[9 ] Department of Pediatrics, Oita University Hospital, Yufu, Japan.

[10 ] Department of Pediatrics, Ehime University Hospital, Toon, Japan.

[11 ] Department of Pediatrics, Sumitomo Besshi Hospital, Niihama, Japan.

[12 ] Department of Pediatrics, Asahikawa Medical University Hospital, Asahikawa, Japan.

[13 ] Department of Pediatrics, Asahikawa-Kosei General Hospital, Asahikawa, Japan.

[14 ] Department of Pediatrics, JR Sendai Hospital, Sendai, Japan.

[15 ] Department of Pediatrics, Saitama Medical University Hospital, Saitama, Japan.

[16 ] Department of Pediatrics, Niigata University Medical and Dental Hospital, Niigata, Japan.

[17 ] Department of Pediatrics, Nagano Red Cross Hospital, Nagano, Japan.

[18 ] Department of Pediatrics, Shinshu Ueda Medical Center, Ueda, Japan.

[19 ] Department of Pediatrics, Dokkyo Medical University Hospital, Shimotsuga, Japan.

[20 ] Department of Pediatrics, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan.

[21 ] Department of Pediatrics, Yokosuka Kyosai Hospital, Yokosuka, Japan.

[22 ] Department of Pediatrics, Kitasato University Hospital, Sagamihara, Japan.

[23 ] Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo, Japan.

[24 ] Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan.

[25 ] Department of Pediatrics, National Mie Hospital, Tsu, Japan.

[26 ] Department of Pediatrics, Osaka Medical College, Takatsuki, Japan.

[27 ] Department of Pediatrics, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.

[28 ] Department of Pediatrics, Tottori University Faculty of Medicine, Yonago, Japan.

[29 ] Department of Pediatrics, Tottori Prefectural Kousei Hospital, Kurayoshi, Japan.

[30 ] Department of Pediatrics, Teine Keijinkai Hospital, Sapporo, Japan.

[31 ] Department of Early Childhood Care and Education, Seitoku University Junior College, Matsudo, Japan.

[32 ] Department of Pediatrics, Kanazawa University, Kanazawa, Japan.

[33 ] Department of Pediatrics, University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan.

[34 ] Takahashi Clinic, Kobe, Japan.

[35 ] Department of Pediatrics, Teikyo University Chiba Medical Center, Ichihara, Japan.

[36 ] Matsuo Kodomo Clinic, Kyoto, Japan.

[37 ] Department of Metabolism and Endocrinology, Saitama Children's Medical Center, Saitama, Japan.

[38 ] Department of Pediatrics, University of Yamanashi Hospital, Chuo, Japan.

[39 ] Miyanosawa Koike Child Clinic, Sapporo, Japan.

[40 ] Division of Endocrinology and Metabolism, Department of Medical Subspecialties, National Medical Center for Children and Mothers, Tokyo, Japan.

[41 ] Teno Clinic, Izumo, Japan.

[42 ] Department of Pediatrics, Chuno Kosei Hospital, Seki, Japan.

[43 ] Department of Pediatrics, Osaka City General Hospital, Osaka, Japan.

[44 ] Department of Pediatrics, Osaka Police Hospital, Osaka, Japan.

[45 ] Igarashi Children's Clinic, Sendai, Japan.

[46 ] Department of Pediatrics, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.

Article

DOI: 10.1111/dme.13175

PubMed ID: 27352912

SO-VID: f2ee55bd-f2ab-4300-bd03-2b7626888de0

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