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      Resveratrol Alleviates Inflammatory Responses and Oxidative Stress in Rat Kidney Ischemia-Reperfusion Injury and H<sub>2</sub>O<sub>2</sub>-Induced NRK-52E Cells via the Nrf2/TLR4/NF-κB Pathway

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      Cellular Physiology and Biochemistry

      S. Karger AG

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          Abstract

          Ischemia-reperfusion injury (IRI) is one of the major causes of postoperative renal allograft dysfunction, which is mainly the result of proinflammatory reactions including inflammatory responses, oxidative stress, and metabolic disorders. Resveratrol (RSV) plays an important role in protecting various organs in IRI because it reduces oxidative stress, lessens the inflammatory response, and exerts anti-apoptotic effects. The aim of this study was to demonstrate the renoprotective effect of RSV in inhibiting inflammatory responses, reducing oxidative stress, and decreasing cell apoptosis in vivo and in vitro.

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          Author and article information

          Journal
          Cellular Physiology and Biochemistry
          Cell Physiol Biochem
          S. Karger AG
          1015-8987
          1421-9778
          March 6 2018
          2018
          February 22 2018
          : 45
          : 4
          : 1677-1689
          Article
          10.1159/000487735
          29490296
          f3099b13-d52b-44af-949b-30d4ab35315c
          © 2018

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