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Ischemia-reperfusion injury (IRI) is one of the major causes of postoperative renal
allograft dysfunction, which is mainly the result of proinflammatory reactions including
inflammatory responses, oxidative stress, and metabolic disorders. Resveratrol (RSV)
plays an important role in protecting various organs in IRI because it reduces oxidative
stress, lessens the inflammatory response, and exerts anti-apoptotic effects. The
aim of this study was to demonstrate the renoprotective effect of RSV in inhibiting
inflammatory responses, reducing oxidative stress, and decreasing cell apoptosis in
vivo and in vitro.