17
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Aging-related changes in the nigral angiotensin system enhances proinflammatory and pro-oxidative markers and 6-OHDA-induced dopaminergic degeneration.

      Neurobiology of Aging
      Aging, metabolism, pathology, physiology, Angiotensin II, Angiotensin II Type 1 Receptor Blockers, pharmacology, Animals, Benzimidazoles, Dopaminergic Neurons, Inflammation Mediators, Interleukin-1beta, Male, Molecular Targeted Therapy, NADPH Oxidase, Nerve Degeneration, Oxidative Stress, Oxidopamine, Parkinson Disease, etiology, therapy, Rats, Rats, Sprague-Dawley, Reactive Oxygen Species, Receptor, Angiotensin, Type 1, Substantia Nigra, Tetrazoles, Tumor Necrosis Factor-alpha

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          An age-related proinflammatory, pro-oxidant state in the nigra may increase the vulnerability of dopaminergic neurons to additional damage. Angiotensin II, via type 1 (AT1) receptors, is one of the most important known inflammation and oxidative stress inducers. However, it is not known if there are age-related changes in the nigral angiotensin system. In aged rats, we observed increased activation of the nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase) complex and increased levels of the proinflammatory cytokines interleukin (IL)-1β and tumor necrosis factor (TNF)-α, which indicate pro-oxidative, proinflammatory state in the nigra. We also observed enhanced 6-hydroxydopamine (6-OHDA)-induced dopaminergic cell death in aged rats. This is associated with increased expression of AT1 receptors and decreased expression of AT2 receptors in aged rats, and is reduced by treatment with the AT1 antagonist candesartan. The present results indicate that brain angiotensin is involved in changes that may increase the risk of Parkinson's disease with aging. Furthermore, the results suggest that manipulation of the brain angiotensin system may constitute an effective neuroprotective strategy against aging-related risk of dopaminergic degeneration. Copyright © 2012 Elsevier Inc. All rights reserved.

          Related collections

          Author and article information

          Comments

          Comment on this article