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      Multilineage gene expression precedes commitment in the hemopoietic system.

      , , , , , ,
      Genes & Development
      Cold Spring Harbor Laboratory

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          Abstract

          We have tested the hypothesis that multipotential hemopoietic stem and progenitor cells prime several different lineage-affiliated programs of gene activity prior to unilineage commitment and differentiation. Using single cell RT-PCR we show that erythroid (beta-globin) and myeloid (myeloperoxidase) gene expression programs can be initiated by the same cell prior to exclusive commitment to the erythroid or granulocytic lineages. Furthermore, the multipotential state is characterized by the coexpression of several lineage-affiliated cytokine receptors. These data support a model of hemopoietic lineage specification in which unilineage commitment is prefaced by a "promiscuous" phase of multilineage locus activation.

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          Author and article information

          Journal
          Genes & Development
          Genes & Development
          Cold Spring Harbor Laboratory
          0890-9369
          March 15 1997
          March 15 1997
          : 11
          : 6
          : 774-785
          Article
          10.1101/gad.11.6.774
          9087431
          f30f35a4-7e70-4c0c-a7bd-68c8e3e71ea4
          © 1997
          History

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