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      Nonlinear Input-Output Functions of Motoneurons

      1 , 1 , 2

      Physiology

      American Physiological Society

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          Abstract

          All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na + and Ca 2+ channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.

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          Most cited references 1

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          Spinal and Supraspinal Mechanisms of Voluntary Motor Control and Locomotion

           Binder MD (1981)
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            Author and article information

            Journal
            Physiology
            Physiology
            American Physiological Society
            1548-9213
            1548-9221
            January 01 2020
            January 01 2020
            : 35
            : 1
            : 31-39
            Affiliations
            [1 ]Department of Physiology & Biophysics, University of Washington School of Medicine, Seattle, Washington
            [2 ]Departments of Physiology, Physical Medicine & Rehabilitation, Physical Therapy & Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois
            Article
            10.1152/physiol.00026.2019
            7132324
            31799904
            © 2020

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