Nonlinear Input-Output Functions of Motoneurons

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Abstract

All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na ⁺ and Ca ²⁺ channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.

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Most cited references 1

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Spinal and Supraspinal Mechanisms of Voluntary Motor Control and Locomotion

Binder MD (1981)

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Author and article information

Journal

Title: Physiology

Abbreviated Title: Physiology

Publisher: American Physiological Society

ISSN (Print): 1548-9213

ISSN (Electronic): 1548-9221

Publication date Created: January 01 2020

Publication date (Print): January 01 2020

Volume: 35

Issue: 1

Pages: 31-39

Affiliations

[1 ]Department of Physiology & Biophysics, University of Washington School of Medicine, Seattle, Washington

[2 ]Departments of Physiology, Physical Medicine & Rehabilitation, Physical Therapy & Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois