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      5-HT and motor control: a hypothesis

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      Trends in Neurosciences

      Elsevier BV

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          Abstract

          The activity of 5-HT-containing neurons in the brain is activated preferentially in association with motor output in cats. This is especially apparent during changes in muscle tone and during responses mediated by central pattern generators; such as chewing, locomotion and respiration. These and other data support the hypothesis that the primary functions of the 5-HT system in the brain are to facilitate motor output and concurrently inhibit sensory information processing. This hypothesis is applicable phylogenetically, from invertebrates to mammals.

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          Most cited references 20

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          Dorsal raphe neurons: depression of firing during sleep in cats.

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            Distribution of serotonin-immunoreactivity in the central nervous system of the rat—Cell bodies and terminals

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              Neuronal network generating locomotor behavior in lamprey: circuitry, transmitters, membrane properties, and simulation.

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                Author and article information

                Journal
                Trends in Neurosciences
                Trends in Neurosciences
                Elsevier BV
                01662236
                September 1993
                September 1993
                : 16
                : 9
                : 346-352
                Article
                10.1016/0166-2236(93)90090-9
                7694403
                © 1993

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