There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
The activity of 5-HT-containing neurons in the brain is activated preferentially in
association with motor output in cats. This is especially apparent during changes
in muscle tone and during responses mediated by central pattern generators; such as
chewing, locomotion and respiration. These and other data support the hypothesis that
the primary functions of the 5-HT system in the brain are to facilitate motor output
and concurrently inhibit sensory information processing. This hypothesis is applicable
phylogenetically, from invertebrates to mammals.