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      Osteoporosis in patients with diabetes mellitus.

      Journal of Bone and Mineral Research
      Adult, Bone Density, Diabetes Mellitus, Type 1, complications, Diabetes Mellitus, Type 2, Female, Humans, Male, Osteoporosis, epidemiology, Phenotype, Risk Factors

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          Abstract

          Demographic trends with longer life expectancy and a lifestyle characterized by low physical activity and high-energy food intake contribute to an increasing incidence of diabetes mellitus and osteoporosis. Diabetes mellitus is a risk factor for osteoporotic fractures. Patients with recent onset of type 1 diabetes mellitus may have impaired bone formation because of the absence of the anabolic effects of insulin and amylin, whereas in long-standing type 1 diabetes mellitus, vascular complications may account for low bone mass and increased fracture risk. Patients with type 2 diabetes mellitus display an increased fracture risk despite a higher BMD, which is mainly attributable to the increased risk of falling. Strategies to improve BMD and to prevent osteoporotic fractures in patients with type 1 diabetes mellitus may include optimal glycemic control and aggressive prevention and treatment of vascular complications. Patients with type 2 diabetes mellitus may additionally benefit from early visual assessment, regular exercise to improve muscle strength and balance, and specific measures for preventing falls.

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          Author and article information

          Journal
          17501667
          10.1359/jbmr.070510

          Chemistry
          Adult,Bone Density,Diabetes Mellitus, Type 1,complications,Diabetes Mellitus, Type 2,Female,Humans,Male,Osteoporosis,epidemiology,Phenotype,Risk Factors

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